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. 2012 Dec 20;22(9):1408–1418. doi: 10.1089/scd.2012.0445

FIG. 1.

FIG. 1.

Endothelial progenitor cell (EPC) transplantation improves blood flow in hind-limb ischemia in diabetic mice. Control (I) or streptozotocin-injected diabetic mice (D/I) underwent left femoral artery ligation, and the diabetic mice were injected intramuscularly with saline (D/I/S) or EPC (D/I/EPC). (A) Laser Doppler perfusion images were taken before surgery (Pre-op) and immediately after surgery (POD 0) or at 7 days after surgery (POD 7). The upper panels show typical results, while the lower panel shows the mean blood flow rate expressed as the ratio of the value for the ischemic (left) hind limb to that of the contralateral (right) nonischemic hind limb compared with the ratio immediately after surgery (POD 0) in the I group. (B) Functional status of the ischemic hind limb at POD 7. The upper panels show representative photographs, and the lower panel depicts the statistical analysis of the functional score. n=8 per group, *P<0.05, compared with the D/I/S group. †, <0.05, compare with the D/I/EPC at POD 3 or at POD 0.