FIG. 3.

MSC suppressive effect on T-cell proliferation. Proliferative responses expressed as cpm on ³H-TdR incorporation of unstimulated and activator-induced T-lymphocytes in the presence or absence of BM MSCs from allogeneic normal (upper panel) or patient (lower panel) MSCs. Data are expressed as mean (±SEM) of triplicates of 4 separate experiments. A comparison of cpm in the presence or absence of MSCs was performed by means of the nonparametric Mann–Whitney test, and the P values are depicted. cpm, counts per minute; SEM, standard error of the mean.