Table 3.
Fluorescence In Situ Hybridization Analysis of Bone Marrow Hematopoietic Cells and Mesenchymal Stem Cells from Chronic Lymphocytic Leukemia Patients
| UPN | Genetic aberrations in BM hematopoietic cells (%) | MSC passage | Genetic aberrations in BM MSCs |
|---|---|---|---|
| 1 | TP53-del (31%) trisomy 12 (36%) |
2 | No genetic abnormality was detected |
| 2 | ATM-del (51%) RB-del (58%) |
2 | No genetic abnormality was detected |
| 3 | RB-del (38%) trisomy 12 (34%) |
2 | No genetic abnormality was detected |
| 4 | RB-del (17%) trisomy 12 (27%) |
2 | No genetic abnormality was detected |
| 5 | Homozygous for RB-del (87%) | 2 | No genetic abnormality was detected |
| 6 | RB-del (30%) | 2 | No genetic abnormality was detected |
| 7 | RB-del (61%) | 2 | No genetic abnormality was detected |
| 8 | No genetic abnormality was detected | 2 | No genetic abnormality was detected |
| 9 | No genetic abnormality was detected | 2 | No genetic abnormality was detected |
| 10 | No genetic abnormality was detected | 2 | No genetic abnormality was detected |
| 11 | RB-del (50%) | 2 | No genetic abnormality was detected |
FISH, fluorescence in situ hybridization; BM, bone marrow; del, deletion; RB, retinoblastoma; ATM, ataxia telangiectasia mutated.