Table 4.
Studies comparing DWI with contrast-enhanced MRI for the detection of focal liver lesions
| Year | Authors | No. of patients | Comparison | Findings |
|---|---|---|---|---|
| 2012 | Song et al.[94] | 158 | Gd-EOB-DTPA | No difference in diagnostic accuracy for DWI performed with or without contrast enhancement |
| 2012 | Kim et al.[95] | 86 | Gd-EOB-DTPA | Combined DWI and Gd-EOB-DTPA imaging showed higher accuracy and sensitivity |
| 2012 | Holzepfel et al.[55] | 36 | Gd-EOB-DTPA | Combined DWI and Gd-EOB-DTPA improved detection of lesions <1 cm in diameter |
| 2011 | Chung et al.[96] | 47 | Gd-EOB-DTPA | Combination of DWI and Gd-EOB-DTPA showed higher accuracy for detection of metastases |
| 2012 | Koh et al.[8] | 72 | Gd-EOB-DTPA | Improves diagnostic accuracy using combination of DWI and Gd-EOB-DTPA enhanced imaging |
| 2011 | Löwenthal et al.[97] | 73 | Gd-EOB-DTPA | DWI good for detecting small metastases |
| 2010 | Shimada et al.[98] | 45 | Gd-EOB-DTPA | Gd-EOB-DTPA MRI showed higher accuracy |
| 2009 | Coenegrachts et al.[89] | 25 | SPIO, TSE T2W | Non-contrast single-shot echo-planar imaging-DWI best for lesion detection |
| 2006 | Nasu et al.[99] | 24 | SPIO | DWI + T1/T2 resulted in highest detection rate compared with SPIO-enhanced imaging |
| 2008 | Koh et al.[54] | 33 | Mn-DPDP T1W | Adding DWI to Mn-DPDP resulted in highest detection rate |
DTPA, diethylenetriaminepentaacetic acid; EOB, ethoxybenzyl; Mn-DPDP, mangafodipir trisodium; SPIO, superparamagnetic iron oxide; TSE, turbo spin-echo.