. Author manuscript; available in PMC: 2013 Apr 18.

Published in final edited form as: Pediatr Res. 2012 Aug;72(2):212–220. doi: 10.1038/pr.2012.56

Table 3. Mixed Model Analysis for Cytokines Showing Significant Sepsis Group and Time Interaction After Controlling for Significant Covariates.

Cytokine	Effect – F Value (Probability>F)					Significant Covariates (p)
	Group	Postnatal Age	Group^* Age^a	Pre- vs. Post-Infection status	Pre-/Post-infection status^* Group^b
	IFN-γ	0.011	<0.0001	<0.0001	0.0005		0.0001	Center^‡
Preterm labor^*	IFN-γ	0.011	<0.0001	<0.0001	0.0005		0.0001
IL-10	0.0002	<0.0001	<0.0001	0.0075	0.0067	Center^‡
						Oxygen^**
						NEC^*
IL-18	0.0097	<0.0001	0.0283	0.0009	0.0265	Center^‡
						GA^**
						Hypertension^**
TGF-β	0.0024	<0.001	0.0007	<0.0001	0.0013	Center^‡
						GA^**
						Preterm labor^**
						PDA^†
						NEC^**
TNF-α	0.0162	0.0025	0.0064	NS	NS	Center^‡
TNF-α	0.0162	0.0025	0.0064	NS	NS	PDA^*

interaction of group and age

interaction of pre- or post-infection status and Group

p<0.05

^**

p<0.01

^†

p<0.001

^‡

p<0.0001