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. Author manuscript; available in PMC: 2013 Apr 18.

Published in final edited form as: Pediatr Res. 2012 Aug;72(2):212–220. doi: 10.1038/pr.2012.56

Table 5. Area under the Curve for Cytokines Significantly Different Between Groups in the Pre- and Post-Infection Phase.

PRE-INFECTION PHASE
Cytokine	Analyses	D14			D21
		BS vs. No Sepsis	FS vs. No Sepsis	BS vs. FS	BS vs. No Sepsis	FS vs. No Sepsis	BS vs. FS
		IL-10	Unadjusted	0.56 (0.51-0.60)^**	0.59 (0.51-0.67)^**	0.54 (0.45-0.62)^**			0.61 (0.51-0.72)^*
Adjusted	0.72 (0.69-0.77) ^†	IL-10	0.81 (0.76-0.86)^‡			0.80 (0.74-0.86)^*	0.70 (0.61-0.79)^*
IL-18	Unadjusted	0.56 (0.52-0.61)^*				0.68 (0.59-0.76)^*
IL-18	Adjusted	0.61 (0.56-0.65)^*
TGF-β	Unadjusted	0.56 (0.51-0.60)^*	0.64 (0.57-0.71)^**			0.67 (0.58-0.77)^*
TGF-β	Adjusted
POST-INFECTION PHASE
Cytokine	Analyses	D14			D21
Cytokine	Analyses	BS vs. No Sepsis	FS vs. No Sepsis	BS vs. FS	BS vs. No Sepsis	FS vs. No Sepsis	BS vs. FS
IL-10	Unadjusted		0.73 (0.59-0.87)^**	0.71 (0.56-0.86)^*			0.58 (0.45-0.69)^**
IL-10	Adjusted		0.87 (0.76-0.98)^**	0.79 (0.65-0.92)^*		0.85 (0.78-0.91)^*	0.81 (0.73-0.89)^**
IL-18	Unadjusted	0.58 (0.51-0.64)^*	0.72 (0.62-0.82)^*		0.59 (0.54-0.64)^*	0.78 (0.72-0.85)^‡	0.70 (0.61-0.79)^**
IL-18	Adjusted	0.66 (0.61-0.72)^*			0.61 (0.56-0.66)^*	0.85 (0.79-0.91)^**	0.80 (0.73-0.87)^*
TGF-β	Unadjusted	0.60 (0.53-0.66)^*	0.79 (0.66-0.92)^**		0.60^†	0.85^‡	0.78^‡
TGF-β	Adjusted		0.91 (0.82-1.0)^*		0.63^*	0.92^‡	0.85^†

Numbers represent AUC (95% Confidence Limits)

^*

p<0.05

^**

p<0.01

^†

p<0.001

^‡

p<0.0001