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. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Dev Biol. 2008 Apr 15;320(1):19–29. doi: 10.1016/j.ydbio.2008.03.045

Fig. 3.

Fig. 3

Tooth development following initiation is also delayed in Wnt1-Cre;Alk5fl/fl mice. Immunohistochemistry of Shh and Amelogenin in wild-type and Wnt1-Cre;Alk5fl/fl sections. Black arrows indicate location of expression. White arrows indicate the locations of tooth germs in Wnt1-Cre;Alk5fl/fl embryos. (A–D) Shh expression is detectable in the incisors (A) and molars (C) of wild-type embryos but not in incisors (B) or molars (D) of Wnt1-Cre;Alk5fl/fl littermate embryos. (E–H) At E17.5, Shh expression is clearly visible in wild-type incisors (E) and molars (G) and Wnt1-Cre;Alk5fl/fl incisors (F) and molars (H). (I, J) Amelogenin is expressed in the wild-type newborn molar tooth germ (I) but not the Wnt1-Cre;Alk5fl/fl newborn molar tooth germ (J). Dotted lines outline tooth germs. Scale bar in panel A=100 μm.