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. Author manuscript; available in PMC: 2013 Apr 18.
Published in final edited form as: Dev Biol. 2008 Apr 15;320(1):19–29. doi: 10.1016/j.ydbio.2008.03.045

Fig. 7.

Fig. 7

Increased apoptosis in Wnt1-Cre;Alk5fl/fl embryos. TUNEL assays to detect cell death in E12.5 wild-type and Wnt1-Cre;Alk5fl/fl embryos. (A, B) Sagittal sections from the proximal region (schematic diagram on the left). (C, D) Sagittal sections from the distal region (schematic diagram on the left). Oral and aboral sides or the mandible were separated with dotted straight lines. (E, F) Sagittal sections from the epithelium of tooth-forming regions. (G and H) Histogram showing statistically significant increase in the ratio of apoptotic cells in the proximal, aboral region of Wnt1-Cre;Alk5fl/fl mutants and in the oral epithelium of Wnt1-Cre;Alk5fl/fl mutants compared with wild-type controls. Arrowheads indicate TUNEL signals. Broken lines in F outline the epithelium of the mandible and maxilla processes. WT, wild-type. mutant, Wnt1-Cre;Alk5fl/fl mutant. mx, maxilla process. md, mandible process. fb, forebrain. np, nasal process. Scale bar in panel A=100 μm.