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. 2013 Apr 18;9(4):e1003222. doi: 10.1371/journal.ppat.1003222

Figure 6. miR-155 drives a feedback regulatory loop.

Figure 6

(A) miR-155 directly regulates the BIC promoter. In unparasitized BL3 cells, transfection with miR-155, siDET1 or c-Jun led to induction of the BIC-Luciferase reporter. Relative luciferase results are shown compared to control transfections in BL3 cells (dark grey bars) (average ± sd, n = 3). (B) In contrast, in TBL3 cells, inhibiting miR-155 or c-Jun (with plasmids encoding miR-155 Sponge or Dominant Negative DN-c-Jun, respectively) led to reduced BIC-Luciferase reporter activity (average ± sd, n = 3). *p<0.05, **p<0.01, ***p<0.001.