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. 2013 Apr 18;9(4):e1003007. doi: 10.1371/journal.pcbi.1003007

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© 2013 Fuchs et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Ranking of 49 proteases with respective MEROPS clan (including the added 2 glutamic proteases) in respect to their total cleavage entropy S_cleavage. Specific proteases (S_Cleavage<6.8, corresponding to an average subpocket cleavage entropy S_i of 0.85 over eight investigated subpockets)are highlighted in yellow. No protease in the core test set of 47 proteases is found to be highly specific (S_Cleavage<4.0, reflecting an average S_i of lower than 0.5 over the whole binding site region of S₄-S_4′). Scytalidoglutamic peptidase present in the extended test set exhibits such strict substrate cleavage with a total cleavage entropy S_Cleavage of 2.932 owing to substrate recognition spreading over 7 highly specific subpockets (compare Figure 5).