Table 1. Summary of genomic features of the FB genome and three T. pallidum ssp. pertenue strains (Samoa D, CDC-2 and Gauthier).
Genome parameter | Fribourg-Blanc isolate | Samoa D | CDC-2 | Gauthier |
GeneBank accession number | CP003902.1 | CP002374.1 | CP002375.1 | CP002376.1 |
Genome size | 1,140,481 bp | 1,139,330 bp | 1,139,744 bp | 1,139,417 bp |
G+C content | 52.80% | 52.80% | 52.80% | 52.80% |
No. of fused genesa | 25 (52 corresponding genes in the Nichols genome) | 25 (52 corresponding genes in the Nichols genome) | 24 (50 corresponding genes in the Nichols genome) | 24 (50 corresponding genes in the Nichols genome) |
Sum of the intergenic region lengths (% of the genome length) | 52,785 bp (4.63 %) | 52,844 bp (4.64%) | 52,963 bp (4.65%) | 53,300 bp (4.68%) |
Average/median gene length | 982.6/831.0 bp | 980.3/831.0 bp | 980.4/831.0 bp | 979.3/831.0 bp |
No. of predicted protein-encoding genes | 1065 | 1068 | 1068 | 1068 |
No. of genes encoded on plus/minus DNA strand | 599/523 | 600/525 | 600/525 | 600/525 |
No. of genes coding for proteins with predicted function | 640 | 640 | 640 | 640 |
No. of genes coding for treponemal conserved hypothetical proteins | 139 | 140 | 140 | 140 |
No. of genes coding for conserved hypothetical proteins | 141 | 141 | 141 | 141 |
No. of genes coding for hypothetical proteins | 145 | 147 | 147 | 147 |
No. of annotated pseudogenes (no. of all pseudogenes compared to Nichols sequencea) | 3 (14) | 3 (12) | 3 (12) | 3 (12) |
No. of tRNA loci | 45 | 45 | 45 | 45 |
No. of rRNA loci | 6 (2 operons) | 6 (2 operons) | 6 (2 operons) | 6 (2 operons) |
No. of ncRNAs | 3 | 3 | 3 | 3 |
Number of genes in a particular genome which sequence include at least 2 genes predicted in the Nichols genome AE000520.1.