Table 5. Genome differences specific for the FB genome (comprising 630 nucleotides).

	Non-coding sequences (IGR) (altogether 445 bp)		Coding sequences (altogether 185 bp)
Nucleotide difference	Number of changes	Number of mutated nucleotides	Number of changes	Number of mutated nucleotides (relevant protein change)	The most affected gene(s)
deletion	3	2× single bp,1×2 bp, altogether 4 bp	6	3× single bp, altogether 3 bp (protein truncation or elongation); 3, 6 and 42 bp, altogether 51 bp; (protein shortening)	TPFB_0012, 0461a, 0484; TPFB_0370, 0548, 0859
insertion	3	2×2 bp, 1×430 bp (TPFB_0696–TPFB_0697), altogether 434 bp	5	1×2 bp, 1×5 bp, altogether 7 bp (protein truncation); 3×3 bp, altogether 9 bp; (protein elongation)	TPFB_0347, 0040; TPFB_0179, 0279, 0462
substitution	7	7× single bp, altogether 7 bp	117	117 bp (synonymous or nonsynonymous mutations)	TPFB_0117, 0126a, 0316, 0324, 0488, 0620, 0865, 0968

Genome differences specific for the FB genome (comprising 630 nucleotides) in both non-coding (intergenic regions, IGR) and coding regions when compared to TPE strains (Samoa D, CDC-2, Gauthier).

The tprK gene was excluded from this list of changes because of high sequence diversity within TPE strains.