Table 1. Antibody responses of mice vaccinated with MP-12 or the variants.
42 days post vaccination | a-NSs IgG (OD405) | |||||
Virus | Mouse # | Protection | PRNT80 | a-N IgG | Pre | Post |
MP-12 | 14-1 | Dead (7 dpi) | - | 3,200 | 0.11 | - |
14-5 | Dead (8 dpi) | - | 3,200 | 0.11 | - | |
15-3 | Dead (7 dpi) | - | 409,600 | 0.10 | - | |
3-1 | Dead (7 dpi) | - | 800 | 0.14 | - | |
3-3 | Dead (7 dpi) | - | - | 0.12 | - | |
3-5 | Dead (13 dpi) | - | - | 0.14 | - | |
4-1 | Dead (7 dpi) | - | - | 0.12 | - | |
14-4 | Survived | - | 819,200 | 0.63* | 0.74* | |
15-2 | Survived | - | 1,638,400 | 0.12 | 0.29* | |
14-3 | Survived | - | - | 0.11 | 3.50* | |
14-2 | Survived | 2,560 | 12,800 | 0.13 | 1.15* | |
15-4 | Survived | 2,560 | 800 | 0.12 | 0.28* | |
15-5 | Survived | 2,560 | 1,638,400 | 0.38* | 0.50* | |
3-2 | Survived | 640 | 409,600 | 0.12 | 0.42* | |
3-4 | Survived | 640 | 819,200 | 1.84* | 1.74* | |
4-2 | Survived | 640 | 409,600 | 0.13 | 0.88* | |
4-3 | Survived | 640 | 204,800 | 0.09 | 1.05* | |
4-4 | Survived | 640 | 204,800 | 1.05* | 1.08* | |
4-5 | Survived | 640 | 819,200 | 1.45* | 1.86* | |
rMP12-PTNSs | 16-2 | Survived | 2,560 | 6,400 | 0.13 | 0.25* |
16-3 | Survived | 2,560 | 6,400 | 0.12 | 0.23* | |
16-4 | Survived | 160 | 25,600 | 0.11 | 0.27* | |
17-1 | Survived | 2,560 | 819,200 | 0.12 | 0.65* | |
17-2 | Survived | 640 | 102,400 | 0.11 | 0.22* | |
17-3 | Survived | 2,560 | 819,200 | 0.10 | 0.47* | |
17-4 | Survived | 2,560 | 204,800 | 0.12 | 0.25* | |
17-5 | Dead (8 dpi) | - | 3,200 | 0.11 | - | |
16-1 | Dead (10 dpi) | - | 3,200 | 0.13 | - | |
rMP12-SFSNSs | 20-1 | Survived | 160 | 204,800 | 0.18 | 0.48* |
20-2 | Survived | 640 | 819,200 | 0.14 | 0.66* | |
20-3 | Survived | 160 | 204,800 | 0.13 | 0.69* | |
20-4 | Survived | 640 | 409,600 | 0.13 | 0.58* | |
21-3 | Survived | 2,560 | 819,200 | 0.14 | 0.51* | |
21-4 | Survived | 640 | 819,200 | 0.11 | 0.42* | |
21-5 | Survived | - | 204,800 | 0.15 | 1.19* | |
21-1 | Survived | - | 102,400 | 0.15 | 0.76* | |
21-2 | Dead (9 dpi) | - | 102,400 | 0.14 | - | |
rMP12-NSsR173A | 7-1 | Survived | 160 | 400 | 0.10 | 0.57* |
7-4 | Survived | 10 | 800 | 0.13 | 0.14 | |
8-1 | Survived | 10 | 6,400 | 0.15 | 0.54* | |
7-3 | Survived | - | 6,400 | 0.12 | 0.44* | |
8-5 | Survived | - | 800 | 0.13 | 1.20* | |
7-2 | Dead (13 dpi) | - | 400 | 0.12 | - | |
7-5 | Dead (13 dpi) | - | 400 | 0.11 | - | |
8-2 | Dead (9 dpi) | - | 3,200 | 0.11 | - | |
8-3 | Dead (8 dpi) | - | - | 0.10 | - | |
8-4 | Dead (11 dpi) | - | - | 0.10 | - | |
PBS | 12-4 | Survived | - | - | 0.13 | 1.92* |
a-NSs IgG positive (cut-off = 0.204).
Pre: 42 days post vaccination, Post: 21 days post wt RVFV challenge.