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. 2013 Apr 18;8(4):e61923. doi: 10.1371/journal.pone.0061923

Figure 2. Revascularization upon ischemia is PAR2-dependent.

Figure 2

(A) SMA staining was performed to detect collaterals in the ischemic adductor muscles and subsequently quantified. Mean collateral number in WT mice was compared to PAR1-/- mice (B) and PAR2-/- mice. (C) Capillary density was quantified after CD31 staining of ischemic calf muscles. Mean capillary number of WT was compared to PAR1-/- mice (D) and PAR2-/- mice. (E) Images represent the CD31 and SMA stainings of ischemic hind limbs of WT, PAR1-/- and PAR2-/- mice. Arrowheads indicate vessels. Bar, 100 µm. * p<0.05.