Skip to main content
. 2013 Apr 18;8(4):e61923. doi: 10.1371/journal.pone.0061923

Figure 5. Increased accumulation of repair-associated macrophages surrounding collaterals in ischemic hind limbs is PAR2-dependent.

Figure 5

(A) Stainings of CD206-positive macrophages (green) and SMA-positive vessels (red) in non-ischemic (control) and ischemic (ligated) hind limbs of WT, PAR1-/- and PAR2-/- mice are shown. Nuclei were visualized with DAPI (blue). Arrows indicate single macrophages in the non-ischemic adductor. Quantification of the average number of repair-associated macrophages per vessel is indicated on the right. (B) Correlation between the number of CD206-positive macrophages in the ischemic tissues and the expression of CD11b and (C) CD115 on monocytes. ** p<0.01, *** p<0.001.