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. 2013 Apr 18;8(4):e60888. doi: 10.1371/journal.pone.0060888

Figure 1. Disruption of Drosha in VSMCs results in embryonic mortality.

Figure 1

A. Morphology of Drosha cKO (Droshaloxp/loxp/SM22-Cre) and control (Droshaloxp/loxp) embryos at E13.5 and E14.5. B. Vasculature of yolk sac in control and Drosha cKO mice between E13.5 and E14.5. C. Genotyping Drosha cKO mice by PCR showed three different genotypes: wild type (WT), heterozygote, and homozygote. D. The expression of Drosha in umbilical cord at E13.5 was detected by Western blot in cKO and WT mice (n = 5, ***P<0.001).