Table 1. Cofactors that regulate the core promoter-selective functions of TFIID.

Core promoter-selective cofactors	Core promoter element regulated (promoter configuration)
	Positive regulation	Negative regulation
HMGA1	INR (TATA/INR synergy)	TATA
Mediator (PC2)	INR (TATA/INR synergy)	?
Topo I (PC3)	INR (TATA/INR synergy)	TATA
PC4	DPE (Sp1-activated INR/DPE)	TATA?
CK2	DPE (Sp1-activated INR/DPE)	TATA?
NC2 (DR1-DRAP1)	DPE (INR/DPE)	TATA
BTAF1 (MOT1)	DPE (INR/DPE)	TATA

? indicate unknown or possible roles postulated from published data