Table 1. Plasma pharmacokinetic estimates for BALB/c mice, New Zealand white Hra: (NZW) SPF albino rabbits, beagle dogs and cynomolgus monkeys following repeat oral dosing of ST-246 by gavage for 7 consecutive days in New Zealand white Hra: (NZW) SPF albino rabbits and beagle dogs and 28 consecutive days in BALB/c mice and cynomolgus monkeys.
| Animal Species | Dose (mg/kg) | Cl/F (L/h) | VD/F (L) | t1/2 (h) | Tmax (h) |
| Mouse | 2000 | 0.05±0.01 | 0.41±0.17 | 5.81±0.86 | 3.00±1.41 |
| Rabbit | 100 | 11.54±3.42 | 129.02±90.35 | 7.27±3.23 | 1.50±1.41 |
| Monkey | 100 | 15.06±4.33 | 392.95±345.90 | 9.94±2.89 | 3.25±2.76 |
| Dog | 30 | 42.52±13.65 | 178.23±60.45 | 3.10±1.15 | 0.83±0.26 |