Table 4. Comparison of levels of selected inflammatory markers in men with normal and subnormal concentration of total or free testosterone in serum.

Cytokine/Chemokine	All (n = 60)	cFT <220 pmol/L (n = 13)	cFT ≥220 pmol/L (n = 47)	Mean ratio (95% CI)	P adj	P adj BMI	TT <8 nmol/L (n = 12)	TT ≥8 nmol/L (n = 48)	Mean ratio (95% CI)	P adj	P adj BMI
TNFa (pg/mL)	8.6 (1.8)	12 (1.2)	7.7 (1.1)	1.58 (1.14,2.20)	0.007**	0.02*	12 (1.2)	7.7 (1.1)	1.61 (1.16,2.26)	0.006**	0.025*
MIP1a (pg/mL)	15 (2.3)	17 (2.9)	14 (2.2)	1.21 (0.69,2.1)	0.490	0.659	23 (2.0)	14 (2.3)	1.84 (1.06,3.19)	0.030*	0.059
MIP1B (pg/mL)	50 (1.8)	55 (1.2)	47 (1.1)	1.18 (0.82,1.71)	0.371	0.634	60 (5.6)	46 (2.3)	1.30 (0.90,1.88)	0.165	0.398

All data represent back transformed logarithmic means (SD). Univariate regression analysis, adjusted for age and fertility status, and when indicated also for BMI. BMI, body mass index; TT, total testosterone; cFT, calculated free testosterone; MIP1a, macrophage inflammatory protein 1-alpha; MIP1B, macrophage inflammatory protein 1-beta; TNFa, tumor necrosis factor alpha; CI, confidence interval; *, P<0.05; **, P<0.01.