Table 3.
Interactions between LRP1 variants and saturated fat intake for adiposity traits in the Boston Puerto Rican Health Study 1,2
| LRP1 rs1799986 | |||||
|---|---|---|---|---|---|
| Saturated fat intake(% energy intake/d) | CC (n=735) | CT+TT (n=154) | P | P interaction | |
| <9.3 | BMI (kg/m2) | 31.0 ± 0.4 | 31.3 ± 0.4 | 0.5 | 0.006 |
| ≥9.3 | 30.5 ± 0.8 | 33.9 ± 0.8 | 0.001 | ||
| <9.3 | Waist (cm) | 101 ± 0.9 | 100 ± 1.8 | 0.6 | 0.02 |
| ≥9.3 | 103 ± 0.9 | 108 ± 1.7 | 0.008 | ||
| <9.3 | Hip (cm) | 107 ± 0.8 | 106 ± 1.6 | 0.4 | 0.002 |
| ≥9.3 | 108 ± 0.8 | 114 ± 1.6 | 0.003 | ||
| LRP1 rs1800191 | |||||
| Saturated fat intake(% energy intake/d) | GG+GA (n=754) | AA (n=142) | P | P interaction | |
| <9.3 | BMI (kg/m2) | 31 ±0.4 | 29.8 ± 0.7 | 0.1 | 0.4 |
| ≥9.3 | 31.6 ± 0.4 | 31.4 ± 0.8 | 0.8 | ||
| <9.3 | Waist (cm) | 101 ± 0.9 | 100 ± 1.7 | 0.5 | 0.7 |
| ≥9.3 | 103 ± 0.9 | 103 ± 2 | 1 | ||
| <9.3 | Hip (cm) | 107 ± 0.9 | 104 ± 1.6 | 0.1 | 0.4 |
| ≥9.3 | 109 ± 0.8 | 109 ± 1.8 | 0.8 | ||
| LRP1 rs715948 | |||||
| Saturated fat intake(% energy intake/d) | CC (n=484) | CT+TT (n=406) | P | P interaction | |
| <9.3 | BMI (kg/m2) | 31.1 ± 0.5 | 30.6 ± 0.5 | 0.4 | 0.9 |
| ≥9.3 | 32 ± 0.5 | 31.4 ± 0.5 | 0.3 | ||
| <9.3 | Waist (cm) | 101 ±1.1 | 101 ±1.2 | 0.7 | 0.7 |
| ≥9.3 | 104 ± 1 | 103 ± 1.1 | 0.4 | ||
| <9.3 | Hip (cm) | 107 ± 1 | 107 ± 1.1 | 1 | 0.4 |
| ≥9.3 | 110 ± 1 | 108 ± 1 | 0.2 | ||
1
Values are mean±SEM
2
Adjusted for age, sex, physical activity, smoking status, alcohol intake, anti-glycemic medication, ancestral admixture