Domains of Apc are indicated as follows: Hom = homodimerization, Arm = Armadillo repeats, 15 aa = 15 amino acid repeats, 20 aa = 20 amino acid repeats, Serine-Alanine-Methionine-Proline (SAMP)= axin binding, NLS=nuclear localization signals, and C-terminal includes microtubule, EB1 and PDZ binding domains. The Mutation Cluster Region (MCR) is between codons 1250 and 1464.