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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Dev Biol. 2013 Mar 6;377(1):67–78. doi: 10.1016/j.ydbio.2013.02.014

Figure 4. Gfra1 and Nanos3 help control proliferation/pluripotency in the fetal testis.

Figure 4

(A) Incidence of teratomas in 129Sv mice carrying a functional “floxed” allele of Gfra1 or conditionally deleted for Gfra1 using Nanos3Cre. Numbers of testes examined was: Nanos3Cre/+ (N = 12); Gfra1fl/+ (N=6); Gfra1fl/fl (N=49); Gfra1fl/+;Nanos3Cre/+ (N=10); Gfra1fl/fl; Nanos3Cre/+ (N=44). Indicated P value (0.025) is from two-tailed Fisher’s exact test. (B) Incidence of teratomas in 129Sv mice carrying a functional “floxed” allele of Dmrt1 or conditionally deleted with Nanos3Cre. Number of testes examined was: Nanos3Cre/+ (N=22); Dmrt1fl/+ (N=12); Dmrt1fl/fl (N=30); Dmrt1fl/+;Nanos3Cre/+ (N=29); Dmrt1fl/fl;Nanos3Cre/+ (N=34).