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. Author manuscript; available in PMC: 2014 Apr 15.
Published in final edited form as: Clin Cancer Res. 2013 Jan 23;19(8):2048–2060. doi: 10.1158/1078-0432.CCR-12-2422

Figure 2.

Figure 2

IHC staining revealed BCMA expression by normal plasma cells and MM cells but not gastrointestinal epithelial cells. A, and B, BCMA-K562 cells exhibited strong BCMA expression while NGFR-K562 cells did not express BCMA. Isotype-matched control antibodies did not stain either cell line. Staining of sections of C, normal stomach and D, normal rectum showed BCMA-expressing plasma cells in the lamina propria but no BCMA expression by other cells of these organs. IHC staining was performed with both anti-BCMA and isotype-matched control antibodies on consecutive sections. E, Double staining of normal duodenum with anti-BCMA (surface, brown) and anti-MUM1(nuclear, red) revealed BCMA+ plasma cells and plasmacytoid cells. BCMA was not expressed by other cells of the duodenum. 10X and 100X views are shown. F, G, H, Staining of myeloma tissue sections from Myeloma Patients 1 through 3 showed cell-surface BCMA expression on the majority of neoplastic plasma cells. IHC staining was performed with BCMA and isotype-matched control antibodies on consecutive sections.