Table 3.

Multivariable-adjusted^a odds of moderate to severe pain at 2 and 5 years after primary TKA

Variable	Moderate to severe pain at 2 years, odds ratio (95% CI)	P-value	Moderate to severe pain at 5 years, odds ratio (95% CI)	P-value
Heart disease (MI, CHF)	1.0 (0.7, 1.5)	0.97	1.7 (1.1, 2.6)*	0.01*
Peripheral vascular disease	1.1 (0.7, 1.6)	0.70	1.1 (0.6, 2.1)	0.67
Renal disease	1.2 (0.8, 1.8)	0.45	0.7 (0.3, 1.4)	0.27
Chronic obstructive pulmonary disease	1.3 (1.0, 1.8)	0.06	0.9 (0.6, 1.4)	0.66
Diabetes (with or without organ damage)	1.3 (0.9, 1.8)	0.12	1.2 (0.8, 1.9)	0.33
CTD	0.9 (0.5, 1.5)	0.70	0.9 (0.5, 1.6)	0.65
Depression	1.3 (1.0, 1.8)	0.08	1.7 (1.1, 2.5)*	0.01*
Anxiety	1.4 (1.0, 2.0)*	0.05*	1.9 (1.2, 3.1)*	<0.01*

^aMultivariable model simultaneously adjusted for age, gender, BMI, ASA class, distance from medical centre, operative diagnosis, implant fixation (cement status), six Deyo–Charlson comorbidity categories, anxiety and depression.

*Significant values.