Table 2:
Haemodynamic data
| Baseline (prior to sternotomy) | Randomized to GAE (n = 109) |
Randomized to GA (n = 117) |
Treatment difference | P-value | ||
|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | |||
| Mean arterial pressure (mmHg) | 92.2 | 16.9 | 93.0 | 16.7 | ||
| Heart rate (beats/min) | 59.8 | 11.6 | 63.2 | 11.3 | ||
| Central venous pressure (mmHg) | 9.20 | 2.96 | 8.57 | 3.31 | ||
| Intraoperative (after application of stabilizer) | Mean | SE | Mean | SE | ||
| Mean arterial pressure (mmHg) | ||||||
| First anastomosis (LAD) | 72.9 | 1.05 | 74.6 | 1.03 | –1.68 | |
| Second anastomosis (PDA) | 75.0 | 0.99 | 75.8 | 1.10 | –0.77 | |
| Third anastomosis (Cx) | 72.8 | 0.98 | 74.2 | 1.50 | –1.44 | |
| Postoperative | 75.4 | 0.90 | 75.9 | 1.01 | –0.54 | |
| Test for treatment × time interaction | 0.91 | |||||
| Overall estimate of treatment effect | –1.11 (–3.06, 0.84) | 0.26 | ||||
| Heart rate (beats/min) | ||||||
| First anastomosis (LAD) | 62.5 | 1.05 | 67.7 | 1.30 | –5.15 | |
| Second anastomosis (PDA) | 63.7 | 1.19 | 68.2 | 1.42 | –4.48 | |
| Third anastomosis (Cx) | 63.9 | 1.12 | 69.1 | 1.63 | –5.21 | |
| Postoperative | 66.5 | 1.13 | 68.8 | 1.05 | –2.32 | |
| Test for treatment × time interaction | 0.29 | |||||
| Overall estimate of treatment effect | –4.29 (–7.10, –1.48) | 0.003 | ||||
| Central venous pressure (mmHg) | ||||||
| First anastomosis (LAD) | 11.8 | 0.49 | 11.0 | 0.48 | 0.77 (–0.56, 2.10) | 0.25 |
| Second anastomosis (PDA) | 14.0 | 0.64 | 13.4 | 0.62 | 0.57 (–1.18, 2.32) | 0.52 |
| Third anastomosis (Cx) | 13.5 | 0.68 | 11.5 | 0.68 | 2.09 (0.21, 3.96) | 0.03 |
| Postoperative | 9.1 | 0.30 | 9.0 | 0.30 | 0.12 (–0.69, 0.94) | 0.76 |
| Test for treatment × time interaction | 0.05 | |||||
LAD: left anterior descending artery; PDA: posterior descending artery; Cx: circumflex coronary artery.