Figure 1.

Goodness-of-fit diagnostics of the final population pharmacokinetic model of (a,b,c) artesunate and (d,e,f) dihydroartemisinin in children with severe malaria. The broken line represents a locally weighted least-squares regression; the solid line is the line of identity. The observed concentrations, population predictions, and individual predictions were transformed into their logarithms (base 10).