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. 2013 Mar 20;93(5):443–450. doi: 10.1038/clpt.2013.26

Figure 3.

Figure 3

Simulated total first-dose exposure levels (AUC0–12h) of (a) ARS and (b) DHA after the standard 2.4 mg/kg dosing in children at different body weights. Simulated total first-dose exposure levels (AUC0–12h) of (c) ARS and (d) DHA after the suggested adjusted dose regimen (Table 3). Open circles represent median values, and bars indicate the 25th to 75th percentiles of simulations (1,000 simulations at each body weight). The broken line represents the median exposure for the largest weight group (i.e., 700 h × ng/ml and 1,230 h × ng/ml for ARS and DHA, respectively). ARS, artesunate; AUC0–12h, area under the concentration–time curve from time point 0 to 12 h; DHA, dihydroartemisinin.