Table 3.
Change in BMI and WC z-score predicting percent change in risk factors – stratified analyses
| Change of BMI Z-score | Change of WC Z-score | |||||
|---|---|---|---|---|---|---|
| Healthy Weight (n=2311) | Estimate | 95% CI | p-value | Estimate | 95% CI | p-value |
| Male (n=1019) | ||||||
| Triglycerides (mg/dl) | 17.70 | (4.31, 31.09) | 0.01 | 15.63 | (−0.84, 32.1) | 0.06 |
| HDL-C (mg/dl) | −5.35 | (−9.09, −1.6) | 0.01 | −5.86 | (−10.47, −1.25) | 0.01 |
| LDL-C (mg/dl) | 2.89 | (−1.31, 7.08) | 0.18 | 6.22 | (1.06, 11.39) | 0.02 |
| Systolic Blood Pressure (mm.Hg) | 4.41 | (2.02, 6.8) | 0.001 | −1.84 | (−4.78, 1.1) | 0.22 |
| Diastolic Blood Pressure (mm.Hg) | 3.68 | (0.01, 7.35) | 0.05 | 0.15 | (−4.37, 4.67) | 0.95 |
| Glucose (mg/dl) | 1.08 | (−1.16, 3.33) | 0.34 | −0.02 | (−2.78, 2.75) | 0.99 |
| MSRS_Z# | 0.26 | (0.14, 0.38) | <0.001 | 0.06 | (−0.09, 0.2) | 0.45 |
| Female (n=1292) | ||||||
| Triglycerides (mg/dl) | 11.75 | (2.89, 20.6) | 0.01 | 7.76 | (−0.61, 16.13) | 0.07 |
| HDL-C (mg/dl) | −5.54 | (−8.84, −2.24) | <0.001 | −4.00 | (−7.15, −0.85) | 0.01 |
| LDL-C (mg/dl) | 5.54 | (1.57, 9.52) | 0.01 | 2.42 | (−1.34, 6.18) | 0.21 |
| Systolic Blood Pressure (mm.Hg) | 0.78 | (−1.35, 2.91) | 0.47 | 0.82 | (−1.21, 2.84) | 0.43 |
| Diastolic Blood Pressure (mm.Hg) | 0.82 | (−2.29, 3.93) | 0.61 | 0.27 | (−2.68, 3.22) | 0.86 |
| Glucose (mg/dl) | −1.20 | (−3.19, 0.79) | 0.24 | 2.88 | (0.99, 4.78) | <0.001 |
| MSRS_Z# | 0.14 | (0.03, 0.24) | 0.01 | 0.15 | (0.05, 0.25) | <0.001 |
| Change of BMI Z-score | Change of WC Z-score | |||||
|---|---|---|---|---|---|---|
| Overweight (n=899) | Estimate | 95% CI | p-value | Estimate | 95% CI | p-value |
| Male (n=409) | ||||||
| Triglycerides (mg/dl) | 33.00 | (9.13, 56.88) | 0.01 | 4.40 | (−17.88, 26.69) | 0.70 |
| HDL-C (mg/dl) | −6.38 | (−13.4, 0.65) | 0.08 | −4.99 | (−11.58, 1.6) | 0.14 |
| LDL-C (mg/dl) | 9.49 | (1.08, 17.9) | 0.03 | 5.47 | (−2.39, 13.32) | 0.17 |
| Systolic Blood Pressure (mm.Hg) | 6.23 | (1.79, 10.67) | 0.01 | −1.48 | (−5.62, 2.65) | 0.48 |
| Diastolic Blood Pressure (mm.Hg) | 5.11 | (−0.66, 10.89) | 0.08 | 0.32 | (−5.07, 5.7) | 0.91 |
| Glucose (mg/dl) | 0.45 | (−3.25, 4.15) | 0.81 | 3.66 | (0.21, 7.12) | 0.04 |
| MSRS_Z# | 0.30 | (0.1, 0.51) | <0.001 | 0.22 | (0.03, 0.41) | 0.02 |
| Female (n=490) | ||||||
| Triglycerides (mg/dl) | 24.50 | (8.88, 40.12) | <0.001 | 1.33 | (−9.13, 11.78) | 0.80 |
| HDL-C (mg/dl) | −19.36 | (−26.56, −12.17) | <0.001 | 0.05 | (−4.77, 4.88) | 0.98 |
| LDL-C (mg/dl) | 13.85 | (5.13, 22.57) | <0.001 | −3.07 | (−8.89, 2.75) | 0.30 |
| Systolic Blood Pressure (mm.Hg) | 6.68 | (2.94, 10.43) | <0.001 | −0.44 | (−2.96, 2.09) | 0.73 |
| Diastolic Blood Pressure (mm.Hg) | 7.09 | (1.45, 12.73) | 0.01 | −0.49 | (−4.3, 3.32) | 0.80 |
| Glucose (mg/dl) | 2.71 | (−0.67, 6.09) | 0.12 | 0.20 | (−2.06, 2.45) | 0.87 |
| MSRS_Z# | 0.59 | (0.36, 0.81) | <0.001 | 0.02 | (−0.13, 0.17) | 0.77 |
| Obese (n=1393) | Change of BMI Z-score | Change of WC Z-score | ||||
|---|---|---|---|---|---|---|
| Estimate | 95% CI | p-value | Estimate | 95% CI | p-value | |
| Male (n=747) | ||||||
| Triglycerides (mg/dl) | 18.85 | (0.85, 36.85) | 0.04 | 18.26 | (6.83, 29.69) | <0.001 |
| HDL-C (mg/dl) | −9.51 | (−15.74, −3.27) | <0.001 | −5.11 | (−9.07, −1.15) | 0.01 |
| LDL-C (mg/dl) | 11.27 | (3.31, 19.23) | 0.01 | 5.68 | (0.64, 10.73) | 0.03 |
| Systolic Blood Pressure (mm.Hg) | 2.18 | (−1.83, 6.19) | 0.29 | 0.72 | (−1.83, 3.27) | 0.58 |
| Diastolic Blood Pressure (mm.Hg) | 4.62 | (−0.67, 9.9) | 0.09 | 1.53 | (−1.83, 4.89) | 0.37 |
| Glucose (mg/dl) | 3.19 | (0.22, 6.17) | 0.04 | 0.78 | (−1.11, 2.67) | 0.42 |
| MSRS Z# | 0.35 | (0.14, 0.55) | <0.001 | 0.18 | (0.05, 0.31) | 0.01 |
| Female (n=646) | ||||||
| Triglycerides (mg/dl) | 32.14 | (16.76, 47.52) | <0.001 | 2.35 | (−5.58, 10.29) | 0.56 |
| HDL-C (mg/dl) | −19.01 | (−26.44, −11.58) | <0.001 | −3.08 | (−6.91, 0.76) | 0.12 |
| LDL-C (mg/dl) | 15.23 | (6.53, 23.94) | <0.001 | 2.07 | (−2.42, 6.55) | 0.37 |
| Systolic Blood Pressure (mm.Hg) | 3.01 | (−1.27, 7.29) | 0.17 | 0.04 | (−2.16, 2.24) | 0.97 |
| Diastolic Blood Pressure (mm.Hg) | 6.58 | (0.69, 12.47) | 0.03 | 1.94 | (−1.09, 4.96) | 0.21 |
| Glucose (mg/dl) | 4.81 | (1.42, 8.19) | 0.01 | 0.03 | (−1.72, 1.77) | 0.98 |
| MSRS_Z# | 0.64 | (0.42, 0.86) | <0.001 | 0.04 | (−0.07, 0.16) | 0.47 |
*
All models are mutually adjusted for BMI and WC z-score as well as ethnic group, pubertal development and parental education
#
MSRS_Z = Combined multiple risk factor score