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. 2012 Jul 2;32(15):1971–1977. doi: 10.1038/onc.2012.206

Figure 3.

Figure 3

Granule exocytosis pathway is required for NK-cell-mediated killing of senescent cells. Senescent and growing IMR-90 fibroblasts (a, c) or HSCs (b) were co-incubated with YT cells for 12 h (a, b) or with primary NK cells for 2 h (c). Cytotoxicity assays were performed either in the presence of 100 nℳ granule exocytosis inhibitor, CMA or following pre-incubation of the YT or primary NK cells with 25 μℳ Granzyme B inhibitor 3,4-DCI. The graphs represent the average and the the s.e. of triplicate measurements from at least three independent experiments. *P<0.01, **P<0.001, ***P<0.0001.