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. Author manuscript; available in PMC: 2013 Apr 19.
Published in final edited form as: Mol Immunol. 2012 Aug 18;53(0):132–139. doi: 10.1016/j.molimm.2012.07.012

Fig. 7. AcPA inhibition of complement activity in vitro and in vivo.

Fig. 7

E23A inhibits complement activity both in vitro and in vivo. (A) Human O serum was incubated with increasing concentrations of AcPA in 20% DMSO and then added to human AB erythrocytes. Values are the means of three independent experiments. Error bars represent the SEM. (B) Three male Wistar rats received intravenous injection of 20 mg AcPA and one rat received vehicle control ( 20% DMSO). Blood was collected before injection and at 0.5, 4, and 24 hours after injection, from which serum was isolated and tested in hemolytic assays with erythrocytes.