Table 3.
Half-lives of Gompertz hazard increase and hazard ratios for disability (ADL15), cognitive impairment (MMSE24) and depression (HAMD10)
| Explanatory factor | ADL15 | MMSE24 | HAMD10 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate | 2.5%ile | 97.5%ile | Estimate | 2.5%ile | 97.5%ile | Estimate | 2.5%ile | 97.5%ile | |
| Half-life (Gompertz) | 2.77 | 4.56 | 1.99 | – | – | – | 1.80 | 2.55 | 1.39 |
| HR of 40 years at entry | 2.83 | 1.06 | 7.53 | 20.1 | 15.9 | 25.4 | – | – | – |
| HR of 60 years at entry | 4.76 | 1.10 | 20.6 | 90.0 | 63.3 | 128 | – | – | – |
| Ratio 60 years : 40 years | 1.68 | 1.03 | 2.74 | 4.48 | 3.98 | 5.04 | – | – | – |
| HR of selegiline | 0.36 | 0.13 | 0.53 | – | – | – | 0.37 | 0.12 | 0.55 |
| HR of levodopa | – | – | – | – | – | – | – | – | – |
| HR of 10 unit status increase | 2.75 | 2.30 | 3.28 | 4.35 | 1.94 | 9.74 | 1.43 | 1.26 | 1.63 |
HR, hazard ratio.