Table A3.

Dropout model parameters for non-death events as a cause of dropout. RSE (in parentheses) is the relative standard error calculated as a percentage of the parameter point estimate

Parameter	Estimate (RSE%)	Units
β0,Gompertz,1	0.0764 (22.3)	1/year
β1,Gompertz,1	−0.417 (21.9)	1/year
βselegiline	−1.6 (13.2)	Selegiline used
βDS	0.0391 (16.9)	1/UPDRS
β0,Gompertz,2	0.0525 (139)	1/year × 109
β1,Gompertz,2	3.4 (5.6)	1/year
β0,Weibull	0.303 (135)	1/year
β1,Weibull	2.99 (27.3)	1/(ln(year))

UPDRS, United Parkinson's Disease Rating Scale.

The dropout hazard model h, as a function of time is:

h(time) =β_0,Gompertz,1 * exp(β_1,gompertz,1 * time +β_selegiline * DP +β_DS * status(time)) +β_0,Gompertz,2 * exp(β_1,Gompertz,2 * time) + if(time>0, β_0,Weibull * exp(β_1,Weibull * ln(time)),0)

DP is 1 when selegiline is used and 0 when not. Status(time) is the predicted UPDRS score at time since study entry.