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Pharmacokinetic profiles for ketamine and corresponding metabolites in a representative subject; (A) ketamine, (B) norketamine, (C) dehydronorketamine, and (D) (2S,6S)-/(2R,6R)-HNK. Red circles are measured (S)-enantiomer concentrations, blue circles are measured (R)-enantiomer concentrations and continuous lines are model fitted profiles
