Table 1.
Effects of group II and group III agonists on EPSCs in the three CF regions of the nucleus laminaris
| In the presence of DCG-IV | |||||||
|---|---|---|---|---|---|---|---|
| CF region | Control | DCG-IV | DCG-IV/Control | Control | l-AP4 | l-AP4/Control | |
| High | Amplitude of 1st EPSC (nA) | 2.25 ± 0.82 (6) | 1.69 ± 0.69 (6)* | 0.75 | 2.64 ± 0.62 (4) | 2.28 ± 0.65 (4) | 0.87 |
| CV | 0.09 ± 0.02 (6) | 0.12 ± 0.02 (6) | 1.31 | 0.08 ± 0.01 (4) | 0.09 ± 0.01 (4) | 1.05 | |
| PPR | 0.89 ± 0.12 (3) | 0.88 ± 0.09 (3) | 0.98 | 0.58 ± 0.04 (4) | 0.68 ± 0.03 (4) | 1.16 | |
| Middle | Amplitude of 1st EPSC (nA) | 1.35 ± 0.46 (6) | 0.75 ± 0.29 (6)* | 0.56 | 2.48 ± 0.52 (4) | 1.68 ± 0.43 (4)* | 0.68 |
| CV | 0.11 ± 0.02 (5) | 0.15 ± 0.03 (5)* | 1.44 | 0.12 ± 0.05 (4) | 0.18 ± 0.07 (4)* | 1.57 | |
| PPR | 0.55 ± 0.18 (3) | 0.77 ± 0.18 (3)* | 1.39 | 0.67 ± 0.16 (4) | 0.90 ± 0.14 (4) | 1.34 | |
| Low | Amplitude of 1st EPSC (nA) | 2.31 ± 0.44 (6) | 0.91 ± 0.18 (6)† | 0.39 | 2.01 ± 0.72 (5) | 1.18 ± 0.48 (5)* | 0.58 |
| CV | 0.09 ± 0.02 (6) | 0.18 ± 0.03 (6)† | 2.09 | 0.14 ± 0.03 (5) | 0.20 ± 0.04 (5)* | 1.49 | |
| PPR | 0.70 ± 0.06 (6) | 0.93 ± 0.05 (6)† | 1.32 | 0.91 ± 0.10 (5) | 1.24 ± 0.15 (5)* | 1.37 | |
The effect of l-AP4 was examined in the presence of DCG-IV. CF, characteristic frequency; CV, coefficient of variation; EPSC, excitatory postsynaptic current; PPR, paired pulse ratio. *P < 0.05; †P < 0.01. The number of cells is indicated in parentheses.