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. 2013 Feb 7;121(16):3261–3266. doi: 10.1182/blood-2012-12-472779

Figure 1.

Figure 1

Increased antibody levels detected among LCA+ transfusion recipients. Longitudinal samples of platelet transfusion recipients from the TRAP study that had been previously screened for HLA antibodies using the LCA were screened for HLA antibodies using a multianalyte, bead-based fluorescent Ab detection assay. Peak class I (A) and class II (B) HLA Ab NBG ratios are plotted for LCA− and LCA+ blood recipients, and mean values were compared using a 1-tailed unpaired t-test. ***P < .001. The dashed line marks the cutoff used to distinguish positive and negative results. (C) Samples from platelet transfusion recipients from the TRAP study that had been previously screened for HPA antibodies using an ELISA were screened for HPA antibodies using a new ELISA. The maximum normalized OD value for antibodies against platelet antibodies (excluding HLA antibodies) were plotted for recipients that tested either ELISA− or ELISA+ with the original assay. The dashed line marks the cutoff used to distinguish positive and negative results. Error bars display mean and standard error.