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Active ATPZs cause the formation of a compact 4-R Tau monomer. 4-R Tau K18PL protein was incubated for 1 h at 37 °C in the absence (K18PL) or presence of the active ATPZ, CNDR-51348 (K18PL:51348). The Tau protein was also either treated with an inactive ATPZ, CNDR-51449 (K18PL:51449) or was pre-reduced (K18PL Red) or pre-oxidized (K18PL Ox). The samples were subsequently analyzed by SEC.
