FIGURE 3.

ATPZ-treated 3-R Tau undergoes intermolecular disulfide formation. A, the 3-R Tau K19 protein was incubated for 1 h at 37 °C in the absence (K19) or presence of CNDR-51348 (K19:51348) or CNDR-51449 (K19:51449) or was pre-reduced (K19 red) or pre-oxidized (K19 ox) before SEC analysis. B, K19 or full-length 3-R Tau (T39) were incubated for 1 h in the absence (−) or presence of CNDR-51348 (51348) or CNDR-51449 (51449) or were pre-reduced (R) or pre-oxidized (O) followed by native gel electrophoretic analysis. The bands corresponding to monomer (M) and dimer (D) are indicated.