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. 2013 Feb 26;288(16):11024–11037. doi: 10.1074/jbc.M112.436006

FIGURE 4.

FIGURE 4.

4-R Tau proteins harboring single cysteine mutations form intermolecular disulfide bonds after ATPZ treatment. A, K18PL Tau protein containing the C291A mutation was incubated for 1 h at 37 °C in the absence (C291A) or presence of CNDR-51348 (C291A:51348) or CNDR-51449 (C291A:51449) or was pre-reduced (Reduced) or pre-oxidized (Oxidized) before SEC analysis. B, K18PL Tau protein containing the C322A mutation was incubated for 1 h at 37 °C in the absence (C322A) or presence of CNDR-51348 (C322A:51348) or CNDR-51449 (C322A:51449) or was pre-reduced (Reduced) or pre-oxidized (Oxidized) before SEC analysis.