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. 2013 Mar 5;288(16):11004–11012. doi: 10.1074/jbc.M112.441816

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Class I HDAC inhibitors accelerate wound healing. A, representative pictures of mouse wound healing experiments. Animals were treated topically with TSA (n = 10), ITSA (n = 7), and TSA and ITSA (n = 7) in combination each day. DMSO was used as a solvent control (n = 12). B, kinetics of skin wound healing in CD1 mice treated with TSA, ITSA, and TSA and ITSA in combination. DMSO was used as a control solvent (n = 12). §, p < 0.05 versus solvent. C, immunofluorescence analysis showing the presence of acetylated tubulin in the wound after local TSA administration compared with the solvent. Green, acetylated tubulin; blue, nuclei counterstained with Hoechst (magnification ×20). D, kinetics of skin wound healing in CD1 mice treated with the deacetylase inhibitor MS275 (n = 8) and MC1568 (n = 8). DMSO was used as a control solvent (n = 12). @, p < 0.05 versus solvent. E, kinetics of skin wound healing in CD1 mice treated with TSA (n = 10), Sirtinol (n = 12), and TSA and Sirtinol (n = 7) in combination. DMSO was used as a control solvent (n = 12). § and #, p < 0.05 versus solvent.