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. 2013 Mar 5;288(16):11004–11012. doi: 10.1074/jbc.M112.441816

FIGURE 2.

FIGURE 2.

Sirtuin modulators regulate cell motility, proliferation, and wound healing. A, kinetics of skin wound healing in CD1 mice treated with SIRT modulators. Animals were treated topically with Resv (n = 13), MC2562 (n = 12), or Sirtinol (n = 12) each day. DMSO was used as a solvent control (n = 12). *, °, and #, p < 0.05 versus solvent. B, epithelial gap histological evaluation at day 5. Resv or MC2562 treatment reduces the epithelial gap significantly at day 5 after punching. * and °, p < 0.05 versus solvent. C, bioluminescence imaging of representative MITO-Luc mice experiments. The images were collected on five animals for each treatment, and one representative animal is shown. D, quantification of emitted light from MITO-Luc mouse would healing. * and °, p < 0.05 versus solvent. E, immunofluorescence panels showing keratinocyte activation after wound healing in MITO-Luc mice. Green, keratin 14; red, luciferase. Magnification ×40).