. 2012 Nov 7;1(11):e35. doi: 10.1038/emi.2012.45

Table 1. Characteristics of putative non-structural proteins of ORF1ab in Ty-BatCoV HUK4, Pi-BatCoV HKU5 and HCoV-EMC.

nsp	Putative function/domain^a	Amino acids (first residue^position - last residue^position)
		Ty-BatCoV HKU4	Pi-BatCoV HKU5	HCoV-EMC
nsp1	Unknown	M¹–G¹⁹⁵	M¹–G¹⁹⁵	M¹–G¹⁹³
nsp2	Unknown	D¹⁹⁶–G⁸⁴⁷	D¹⁹⁶–G⁸⁵¹	D¹⁹⁴–G⁸⁵³
nsp3	Putative PL^pro domain	M⁸⁴⁸–G²⁷⁸⁴	A⁸⁵²–G²⁸²⁹	A⁸⁵⁴–G²⁷³⁹
nsp4	Hydrophobic domain	G²⁷⁸⁵–Q³²⁹¹	G²⁸³⁰–Q³³³⁷	G²⁷⁴⁰–Q³²⁴⁷
nsp5	3CL^pro	S³²⁹²–Q³⁵⁹⁷	S³³³⁸–Q³⁶⁴³	S³²⁴⁸–Q³⁵⁵³
nsp6	Hydrophobic domain	S³⁵⁹⁸–Q³⁸⁸⁹	S³⁶⁴⁴–Q³⁹³⁵	S³⁵⁵⁴–Q³⁸⁴⁵
nsp7	Unknown	S³⁸⁹⁰–Q³⁹⁷²	S³⁹³⁶–Q⁴⁰¹⁸	S³⁸⁴⁶–Q³⁹²⁸
nsp8	Unknown	A³⁹⁷³–Q⁴¹⁷¹	A⁴⁰¹⁹–Q⁴²¹⁷	A³⁹²⁹–Q⁴¹²⁷
nsp9	Unknown	N⁴¹⁷²–Q⁴²⁸¹	N⁴²¹⁸–Q⁴³²⁷	N⁴¹²⁸–Q⁴²³⁷
nsp10	Unknown	A⁴²⁸²–Q⁴⁴²⁰	A⁴³²⁸–Q⁴⁴⁶⁶	A⁴²³⁸–Q⁴³⁷⁷
nsp11	Unknown (short peptide at the end of ORF1a)	S⁴⁴²¹–V⁴⁴³⁴	S⁴⁴⁶⁷–L⁴⁴⁸⁰	S⁴³⁷⁸–L⁴³⁹¹
nsp12	RdRp	S⁴⁴²¹–Q⁵³⁵⁴	S⁴⁴⁶⁷–Q⁵⁴⁰⁰	S⁴³⁷⁸–Q⁵³¹⁰
nsp13	Hel	A⁵³⁵⁵–Q⁵⁹⁵²	A⁵⁴⁰¹–Q⁵⁹⁹⁸	A⁵³¹¹–Q⁵⁹⁰⁸
nsp14	ExoN	S⁵⁹⁵³–Q⁶⁴⁷⁵	S⁵⁹⁹⁹–Q⁶⁵²²	S⁵⁹⁰⁹–Q⁶⁴³²
nsp15	XendoU	G⁶⁴⁷⁶–Q⁶⁸¹⁷	G⁶⁵²³–Q⁶⁸⁷¹	G⁶⁴³³–Q⁶⁷⁷⁵
nsp16	2'-O-MT	A⁶⁸¹⁸–L⁷¹¹⁹	A⁶⁸⁷²–R⁷¹⁷⁹	A⁶⁷⁷⁶–R⁷⁰⁷⁸

Abbreviations: ^aPL^pro, papain-like protease ; 3CL^pro, chymotrypsin-like protease; RdRp, RNA-dependent RNA polymerase; Hel, helicase; ExoN, 3'-to-5' exonuclease; XendoU, poly(U)-specific endoribonuclease; 2'-O-MT, S-adenosylmethionine-dependent 2'-O-ribose methyltransferase.