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. Author manuscript; available in PMC: 2014 Mar 28.
Published in final edited form as: J Med Chem. 2013 Mar 7;56(6):2630–2641. doi: 10.1021/jm400058j

Table 1.

In Vivo Antimalarial Efficacy Using a Single Oral Dose of Trioxane Combined with Mefloquine Hydrochloride in P.berghei Infected Mice

trioxane single oral dose (mg/kg)
survival after infection (days) avg survival % parasitemia suppression1
trioxane Mef-HCl
24 6 18 34, 39, 60, 60 48.3 >99.9
25 6 18 30, 60, 60, 60 52.5 >99.9
graphic file with name nihms450796t1.jpg
27 6 18 44, 60, 60, 60 56.0 >99.9
27 120 0 20, 21, 60, 60 40.3 >99.9
graphic file with name nihms450796t2.jpg
32 6 18 27, 60, 60, 60 51.8 >99.9
33 6 18 13, 16, 20, 60 27.3 >99.9
34 6 18 44, 60, 60, 60 56.0 >99.9
35 6 18 16, 20, 30, 30 21.5 >99.9
controls:
vehicle (no drug) 0 0 6, 7, 8, 8 7.3 0
artemether(4b) 6 18 16, 24, 60, 60 40.0 >99.9
mefloquine 0 18 17, 20, 20, 27 21.0 >99.9
1

determined on day 3 post infection