Table 4.
Numbers and percentages of B-cell subpopulationsa in spleen
| Jackson C57BL/6 (n = 3) | IRF5+/+ 15G littermate (n = 4) | IRF5−/− 15G littermate (n = 3) | IRF5−/− 11G with DOCK2 mutation (n = 6) | |
|---|---|---|---|---|
| Total spleen cell number (×106) | 89.2±17.9 (100%) | 93.1±17.0 (100%) | 70.5±13.3 (100%) | 39.4±1.9 (100%) |
| Immature B cells | 8.0±1.5 (9.0%) | 9.5±1.4 (10.2%) | 6.4±0.8 (9.1%) | 2.9±0.3 (7.3%) |
| T1 | 1.7±0.4 (1.9%) | 2.1±0.2 (2.3%) | 1.1±0.3 (1.6%) | 0.4±0.0 (1%) |
| T2 | 4.2±0.8 (4.7%) | 5.1±0.7 (5.5%) | 3.6±0.6 (5.1%) | 1.4±0.1 (3.6%) |
| T3 | 1.4±0.4 (1.6%) | 1.6±0.5 (1.7%) | 1.2±0.3 (1.7%) | 0.7±0.2 (1.8%) |
| Mature B cells | 42.7±9.5 (47.9%) | 43.5±10.9 (46.7%) | 32.2±8.4 (45.7%) | 9.7±0.9 (24.6%) |
| Follicular B cells | 37.1±9.4 (41.6%) | 38.3±10.3 (41.1%) | 28.8±7.7 (40.9%) | 8.6±0.9 (21.8%) |
| Marginal zone B cells | 4.0±0.2 (4.4%) | 3.2±0.4 (3.4%) | 2.3±0.5 (3.3%) | 0.3±0.0 (0.8%) |
aThe B-cell subpopulations were identified as shown in Fig. 1.