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. 2013 Feb 21;24(4):424–430. doi: 10.1089/hum.2012.121

FIG. 2.

FIG. 2.

AAV transduction to liver: (a) Expression of DSG assessed by Western blot analysis in liver in 2/8max (5x1013 GC/Kg); 2/2i8max (5×1013 GC/Kg); 2/8mid (1.5×1013 GC/Kg); 2/2i8mid (1.5×1013 GC/Kg); 2/8min (5x1012 GC/Kg); and 2/2i8min (5×1012 GC/Kg) at 2 months after treatment (Ctrl+; internal laboratory control of Ab specificity). (b) Expression of DSG assessed by Western blot analysis in the liver in 2/8max (5×1013 GC/Kg); 2/2i8max (5×1013 GC/Kg); 2/8mid (1.5×1013 GC/Kg); 2/2i8mid (1.5×1013 GC/Kg); 2/8min (5×1012 GC/Kg); and 2/2i8min (5×1012 GC/Kg) groups at 7 months after treatment (Ctrl+; internal laboratory control of Ab specificity). After normalization (a, b), a percentage is reported that quantify protein expression compared to the sample showing the highest expression level. (c) AAV genome copies for molecules of diploid genome (mdg) extracted from liver of the same animal groups at 7 months after treatment. The mean absolute value is labeled at the top of each bar.