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. 2013 Feb 21;24(4):424–430. doi: 10.1089/hum.2012.121

FIG. 3.

FIG. 3.

DSG expression in skeletal muscle. (a) Expression of DSG assessed by Western blotting analysis of pooled muscles in 2/8max (5×1013 GC/Kg); 2/2i8max (5×1013 GC/Kg), 2/8mid (1.5×1013 GC/Kg); and 2/2i8mid (1.5×1013 GC/Kg) groups at 2 months after treatment (Ctrl+; internal laboratory control of Ab specificity). (b) Expression of DSG assessed by Western blot analysis of pooled muscles in 2/8max (5×1013 GC/Kg); 2/2i8max (5×1013 GC/Kg); 2/8mid (1.5×1013 GC/Kg); and 2/2i8mid (1.5×1013 GC/Kg) groups at 7 months after treatment (Ctrl+; internal laboratory control of Ab specificity). After normalization (a, b), a percentage is reported that quantify protein expression compared to the sample showing the highest expression level. (c) AAV genome copies for molecules of diploid genome extracted from muscles of the same animal groups at 7 months after treatment. The mean absolute value is labeled at the top of each bar.