Table 4.

Gene-GO term enrichment analysis for selected stress-related DEGs (pmk-1Δ_heat/WT_heat) from this study

GO term	Number of genes	Fisher’s exact P valuea	EASE scoreb
Downregulated genes in pmk-1Δ
Cell cycle
GO:0051726 regulation of cell cycle	38	<0.0001	<0.0001
DNA repair/chromatin stability
GO:0006281 DNA repair	38	<0.0001	<0.0001
Molecular chaperones
GO:0051082 unfolded protein binding	16	0.0004	0.0013
GO:0031072 heat-shock protein binding	14	0.0022	0.0065
Protein degradation
GO:0000502 proteasome complex	29	0.0001	0.0001
GO:0051603 proteolysis involved in cellular protein catabolic process	64	0.0001	0.0001
Translation/protein biosynthesis
GO:0003735 structural constituent of ribosome	80	<0.0001	<0.0001
GO:0042254 ribosome biogenesis	29	<0.0001	<0.0001
GO:0006414 translational elongation	9	0.0001	0.0006
GO:0006413 translational initiation	12	0.0001	0.0005
Upregulated genes in pmk-1Δ
“Daf-16 targets”
GO:0007568 aging	42	<0.0001	<0.0001
Stress response
GO:0009408 response to heat	7	0.0064	0.0240
GO:0006979 response to oxidative stress	7	0.0290	0.0790

^aFisher’s exact P value (determined by DAVID 6.7)

^bEASE Score: modified Fisher’s exact P value (determined by DAVID 6.7)