Table 1. Differentially expressed proteins identified from IBS subgroups.
The International Protein Index (IPI), protein description, Gene Ontology (GO) classifications, expression ratio (IBS/control, log2), and correlation between the two MS datasets are tabulated.
| IPI | Description | Biological Process |
Molecular Function |
Cellular Compon ent |
IBS Constipa tion/ Control |
IBS Diarr hea Low Pain/ Contr ol |
IBS Diarr hea High Pain/ Contr ol |
IBS High Pain High Psych/ Control |
Correla tion |
|---|---|---|---|---|---|---|---|---|---|
| IPI00478003 | A2M α-2-macroglobulin | protein homooligomerization | interleukin-8 binding | platelet alpha granule lumen | 0.22 | −0.26 | 0.87 | 1.66 | 0.94 |
| IPI00300786 | AMY1B;AMY1A;AMY1C;AMY2 A α-amylase 1 | carbohydrate metabolic process | alpha-amylase activity | extracellular | 1.22 | 2.74 | 0.42 | 1 | −0.43 |
| IPI00783987 | C3 Complement C3 | G-protein coupled receptor protein signaling pathway | endopeptidase inhibitor activity | extracellular | 0.42 | 0.29 | 0.53 | 1.53 | 0.91 |
| IPI00031564 | GGCT Isoform 1 of γ-glutamylcyclotransferase | N/A | N/A | N/A | −1 | 1.91 | 0 | 0.32 | 0.74 |
| IPI00023728 | GGH γ-glutamyl hydrolase | glutamine metabolic process | exopeptidase activity | lysosome | −0.32 | 0 | 1.14 | −0.74 | 0.26 |
| IPI00026314 | GSN Isoform 1 of Gelsolin | barbed-end actin filament capping | actin binding | actin cytoskeleton | 1.09 | 0 | 1.17 | 0.81 | 0.94 |
| IPI00304808 | KLK1 Isoform 1 of Kallikrein-1 | proteolysis | peptidase activity | N/A | 2.45 | 2.07 | 2.34 | 2.52 | 0.29 |
| IPI00215894 | KNG1 Isoform LMW of Kininogen-1 | elevation of cytosolic calcium ion concentration | cysteine protease inhibitor activity | extracellular | −0.42 | 0.58 | 3.31 | 3.31 | 0.22 |
| IPI00299547 | NGAL Neutrophil gelatinase-associated lipocalin | transport | transporter activity | soluble fraction | −0.36 | 1.58 | 0.74 | 0.15 | 0.75 |
| IPI00022417 | LRG1 Leucine-rich α-2-glycoprotein | N/A | protein binding | membrane | 0.32 | −0.42 | 1 | 1.32 | 0.67 |
| IPI00385172 | MUC1 Mucin 1 Isoform M3 | N/A | hormone activity | integral to plasma membrane | 1 | 1 | 1.81 | 1.46 | 0.77 |
| IPI00301579 | NPC2 highly similar to Epididymal secretor | cholesterol homeostasis | cholesterol binding | lysosome | 1.58 | 1.58 | 3.31 | 1.58 | 0.81 |
| IPI00020091 | ORM2 α-1-acid glycoprotein 2 | acute-phase response | binding | extracellular | 0.10 | −0.11 | 1.44 | 0.36 | 0.83 |
| IPI00013179 | PTGDS Prostaglandin- H2 D-isomerase | prostaglandin biosynthetic process | prostaglandin-D synthase activity | rough endoplasmic reticulum | 1.25 | 0.97 | 1.25 | 0.65 | 0.52 |
| IPI00009027 | REG1A Lithostathine-1- α | positive regulation of cell proliferation | sugar binding | N/A | 1.06 | −0.13 | 0.50 | −0.26 | 0.32 |
| IPI00292946 | SERPINA7 Thyroxine-binding globulin | N/A | serine-type endopeptidase inhibitor activity | extracellular | 0.58 | 0.81 | 2.17 | 2 | 0.99 |
| IPI00010303 | SERPINB4 Serpin B4 | regulation of proteolysis | serine-type endopeptidase inhibitor activity | cytoplasm | 1.58 | 3.31 | 1.58 | 1 | 0.99 |
| IPI00018909 | TFF3 trefoil factor 3 | defense response | N/A | extracellular | 3.31 | 1.58 | 2 | 1.58 | 0.63 |