Table 2. The results of gene-gene co-association contributing to CAD within the lipid metabolism pathway using four different methods.

	PLSPM-based statistic	CCU	PCA-based logistic model	SNP-based logistic model
Co-association	P-value	P-value	P-value	SNP-SNP*	P-value
LRP5-LRP6	0.025	0.393	0.275	rs3736228–rs2302685	0.075
LRP5- PCSK9	0.106	0.566	0.681	rs3736228–rs2495477	0.216
LRP6- PCSK9	0.402	0.496	0.503	rs2284396–rs2483205	0.462

^*Only the SNP pairs with the smallest P-value were presented.