Table 3. Effect of nanocapsulated quercetin on ROS generation (DCF Fluorescence) in different brain regions of ischemia-reperfusion induced young and aged rats.
| Experimental Conditions | DCF-Fluorescence (% of normal) of different brain regions of young and aged rats | |||||||
| Young rats | Aged rats | |||||||
| Cerebral Cortex | Cerebe- llum | Hypoth- alamus | Hippo campus | Cerebral cortex | Cere- bellum | Hypothalamus | Hippo campus | |
| Normal | 101.86±0.844 | 101.65±0.831 | 103.81±0.836 | 102.97±0.841 | 109.8±0.894 | 106.6±0.671 | 107.83±0.618 | 115.88±0.969 |
| Cerebral ischemia reperfused (A) | 431.77±0.849* | 433.5±0.845* | 445.67±0.837* | 478.33±0.869 | 502.7±0.832* | 504.3±0.551* | 507.89±0.771* | 531.72±0.912* |
| (A)+Free QC treated | 427.54±0.824 | 429.43±0.681 | 440.79±0.857 | 466.44±0.776 | 501.4±0.885 | 504.3±0.551 | 505.92±0.662 | 514.36±0.763 |
| (A)+Empty Nanoparticles | 392.54±0.541 | 397.26±0.621 | 413.74±0.431 | 429.37±0.321 | 443.7±0.667 | 489.4±0.427 | 487.57±0.461 | 477.64±0.459 |
| (A)+Nano capsulated QC treated | 110.56±0.808** | 108.66±0.809** | 108.71±0.809** | 112.82±0.875** | 113.3±0.823** | 111.2±0.859** | 114.56±0.860** | 125.92±0.979** |
Values are mean ± SE of rats. *,P<0.001 significantly different from normal; **, P<0.001 significantly different from ischemia-reperfused rats treated.