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. 2013 Apr 19;8(4):e61262. doi: 10.1371/journal.pone.0061262

Table 1. Top ranked up-regulated GAPDH positively associated genes in NSCLC (correlation coefficient greater than or equal to 0.72).

Gene Title Symbol Probe r value GO Definition T/C p value (t-test)
triosephosphate isomerase 1 TPI1 213011_s_at 0.79 glycolysis 1.09 5.06E-45
non-SMC condensinI complex, subunit D2 NCAPD2 201774_s_at 0.79 cell cycle 1.19 8.33E-35
cell division cycle associated 3 CDCA3 221436_s_at 0.78 cell cycle 1.27 3.05E-50
forkhead box M1 FOXM1 202580_x_at 0.77 cell cycle 1.54 5.89E-49
TPX2, microtubule-associated, homolog (Xenopus laevis) TPX2 210052_s_at 0.76 cell cycle 1.62 9.96E-57
centromere protein A CENPA 204962_s_at 0.75 centromere protein 1.59 1.29E-47
karyopherin alpha 2 (RbAG cohort 1, importin alpha 1) KPNA2 211762_s_at 0.75 cell cycle 1.16 4.99E-43
glucose-6-phosphate isomerase GPI 208308_s_at 0.75 glycolysis 1.11 5.81E-44
cyclin B2 CCNB2 202705_at 0.75 cell cycle 1.54 9.85E-56
cell division cycle 20 homolog (S. cerevisiae) CDC20 202870_s_at 0.75 cell cycle 1.66 1.09E-57
cyclin B1 CCNB1 214710_s_at 0.74 cell cycle 1.61 2.68E-57
RAD51 associated protein 1 RAD51AP1 204146_at 0.74 DNA repair 1.32 9.97E-43
solute carrier family 2 (facilitated glucose transporter), member 1 SLC2A1 201250_s_at 0.74 glucose transport 1.45 1.02E-46
ribonucleotide reductase M2 RRM2 209773_s_at 0.74 DNA replication 1.56 2.01E-54
aurora kinase B AURKB 209464_at 0.73 cell cycle 1.43 1.81E-44
replication factor C (activator 1) 4, 37kDa RFC4 204023_at 0.73 DNA replication 1.24 1.91E-38
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 PSMD2 200830_at 0.73 cell cycle 1.06 2.69E-26
kinesin family member 4A KIF4A 218355_at 0.73 microtubule-based movement 1.63 1.52E-56
baculoviral IAP repeat-containing 5 BIRC5 202095_s_at 0.73 cell cycle 1.62 5.74E-56
kinesin family member 2C KIF2C 209408_at 0.72 cell cycle 1.42 6.65E-54
cyclin-dependent kinase inhibitor 3 CDKN3 209714_s_at 0.72 cell cycle 1.53 2.16E-54
ubiquitin-conjugating enzyme E2S UBE2S 202779_s_at 0.72 cell cycle 1.17 3.38E-29
family with sequence similarity 83, member D FAM83D 225687_at 0.72 cell cycle 1.40 5.67E-35
cell division cycle 45 homolog (S. cerevisiae) CDC45 204126_s_at 0.72 cell cycle 1.34 5.28E-43
cyclin A2 CCNA2 203418_at 0.72 cell cycle 1.62 8.53E-49
protein regulator of cytokinesis 1 PRC1 218009_s_at 0.72 cell cycle 1.47 7.11E-51

r = correlation coefficient between GAPDH and current gene expression in NSCLC.

T/C = expression level ratio between cancer and control.